Endocrine Abstracts

Introduction: Subacute thyroiditis (SAT) is an acute inflammatory disorder which can rarely present as pyrexia of unknown origin without other symptoms. Diffuse thyroid heterogeneity, focal hypoechoic areas and decreased/normal gland vascularity are the most common ultrasound findings of SAT. We report a case of asymptomatic SAT presenting as bilateral thyroid nodules and pyrexia of unknown origin.Case Presentation: A 72-year-old male with a history of t...

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...

Bariatric surgery is a common treatment for morbidly obese patients requiring weight loss and/or metabolic control. Vitamin D (VitD) deficiency and bone loss may occur post-operatively and supplementation with high oral doses of Vitamin D is required. Alternatively, intramuscular depot ergocalciferol (vitamin D2) which slowly releases VitD and overcomes the gastrointestinal tract, could be administrated in such patients.Aim: To present a case of severe V...

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

Background: Primary hyperaldosteronism (PHA) is the most frequent type of endocrine hypertension with a prevalence that is continuously rising. Following the introduction of diagnostic tests that consider both the adrenocorticotropic hormone effect andrenin–angiotensin–aldosterone system (RAAS), the post-dexamethasone saline infusion test (D-SIT) and the overnight dexamethasone, captopril, valsartan test (DCVT) using pharmaceutical RAAS blockade, a higher prevalenc...

Introduction: Autonomous aldosterone secretion (AAS) is present in approximately 10% of hypertensives. Adrenal incidentalomas (AI) can be found in up to 19% of hypertensive individuals. However, data on the incidence of AAS in hypertensive patients with AI is scarce. Our aim was to evaluate the adrenal aldosterone secretory profile in patients with adrenal adenomas with and without arterial hypertension.Patients and methods: We investigated 72 normotensi...

Introduction: Patients with adrenal adenomas appear to exhibit an appreciable prevalence of autonomous aldosterone secretion (AAS). Our aim was to evaluate the anti-hypertensive effect of targeted therapy with mineralocorticoid receptor (MR) antagonists in AAS patients.Patients and methods: We studied 60 hypertensive patients, 21 males and 39 females, harboring an adrenal adenoma with AAS. All patients were receiving combination of anti-hypertensive trea...

Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder characterized by the presence of endocrine and nonendocrine tumors. Until recently, more than 450 different germline mutations have been reported in MEN1 patients involving frameshift deletions, insertions, as well as nonsense mutations.Aim: To report a novel mutation in MEN1 gene in a young female with persisting primary hyperparathyroidism.<p class="ab...

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

Background: The renin-angiotensin system is important for blood pressure control. Screening and diagnostic tests used so far to diagnose patients with aldosterone related hypertension does not take into consideration the stimulating ACTH effect on aldosterone secretion.Objective: To assess the role of aldosterone in essential hypertension using a modified suppression test, performed under suppressed ACTH levels.Subjects and methods...